NCA Parameter Expressed as Ratio of Predicted/Observed | Dose | ||||
---|---|---|---|---|---|
0.5 mg/kg | 1 mg/kg | 2 mg/kg | 3 mg/kg | 4.5 mg/kg | |
AUC all | 1.1 | 1.0 | 1.5 | 1.3 | 1.2 |
Observed clearance | 0.9 | 1.0 | 0.7 | 1.2 | 1.0 |
Cmax | 1.6 | 1.1 | 1.2 | 1.2 | 0.8 |
Terminal half-life | 0.5 | 0.5 | 0.6 | 0.3 | 0.7 |
Steady-state volume of distribution | 0.4 | 0.5 | 0.6 | 0.4 | 0.8 |