TABLE 3

EC₅₀ and maximal relaxations (R_Max) to nicotine in the absence and presence of inhibitors

	SHR, 36 weeks		WKY Rats, 36 weeks
	pEC₅₀	R_Max	pEC₅₀	R_Max
		%		%
Vehicle	−6.15 ± 0.68	52.24 ± 9.13	−6.62 ± 0.40	49.73 ± 7.69
Atropine	−6.37 ± 0.54	54.25 ± 0.78	−6.80 ± 0.66	52.83 ± 12.38
Mecamylamine	−6.31 ± 0.58	46.45 ± 22.85	−6.96 ± 0.36	56.62 ± 14.38
Atropine + mecamylamine	−6.41 ± 0.40	47.41 ± 5.63	−6.51 ± 0.33	58.31 ± 9.52
l-NAME	−5.73 ± 0.76	16.26 ± 3.88	−14.36 ± 0.25	−8.65 ± 3.5
UCL 1684 + TRAM-34	−6.51 ± 0.61	49.92 ± 1.9	−7.04 ± 0.31	20.24 ± 6.46
α-Conotoxin	−6.54 ± 0.45	33.22 ± 7.32	−6.40 ± 0.32	40.82 ± 4.85
α-Bungarotoxin	−6.41 ± 0.54	27.25 ± 3.95	−5.99 ± 0.39	34.97 ± 9.13
DHβE	−6.91 ± 0.57	43.10 ± 11.5	−6.85 ± 0.39	38.36 ± 20.14
LY294002	−6.53 ± 0.32	14.03 ± 4.82	−6.52 ± 0.89	22.45 ± 7.81
PD98059	−5.60 ± 1.78	38.98 ± 6	−7.33 ± 0.40	42.23 ± 4.71
SB203580	−5.46 ± 1	25.09 ± 6.28	−7.34 ± 0.38	39.88 ± 13.06
U0126	−7.58 ± 0.24	23.58 ± 8.67	−7.07 ± 0.96	36.53 ± 10.43