TABLE 2

Pharmacological parameters for agonists in stimulating relaxation in the isolated virgin and pregnant uterus and cervix

RelaxantMaximum Relaxation−log EC50
UterusCervixUterusCervix
VirginPregnantVirginPregnantVirginPregnantVirginPregnant
% carbachol contraction remaining[M]
NE21.2 ± 8.42.5 ± 1.210.8 ± 6.938.6 ± 11.86.50 ± 0.236.45 ± 0.115.98 ± 0.566.06 ± 0.46
Isoproterenol1.3 ± 1.00.3 ± 0.310.4 ± 6.120.8 ± 5.59.51 ± 0.159.37 ± 0.119.95 ± 0.378.51 ± 0.58*
Forskolin1.2 ± 0.83.4 ± 3.312.8 ± 2.517.2 ± 6.86.26 ± 0.225.62 ± 0.185.73 ± 0.216.31 ± 0.31
SNP66.8 ± 14.760.4 ± 12.1N.C.N.C.9.01 ± 0.849.23 ± 0.99N.C.N.C.
CGRP**36.9 ± 10.637.6 ± 11.130.4 ± 8.960.4 ± 10.49.35 ± 0.539.10 ± 0.558.11 ± 0.497.64 ± 0.27

  • N.C., not calculable.

  • ↵* Significantly different from virgin value.

  • ↵** EC50 are estimates because maximums may not have been obtained.