TABLE 1

Pharmacological parameters for agonists in stimulating contraction in the isolated virgin and pregnant uterus and cervix

ContractantMaximum Contraction−log EC50
UterusCervixUterusCervix
VirginPregnantVirginPregnantVirginPregnantVirginPregnant
integrated area/mg KCl contraction[M]
PGF2α200.5 ± 13.7169.9 ± 14.529.4 ± 3.833.6 ± 5.36.73 ± 0.196.68 ± 0.287.29 ± 0.427.24 ± 4.39
Oxytocin229.0 ± 15.6301.5 ± 10.770.0 ± 14.8N.C.*8.81 ± 0.269.03 ± 0.179.83 ± 1.22N.C.
Carbachol**262.2 ± 10.9255.7 ± 89.3162.1 ± 19.7233.9 ± 29.75.62 ± 0.0855.47 ± 0.456.09 ± 0.146.14 ± 0.12
5-HT118.1 ± 9.5145.7 ± 7.549.4 ± 6.333.7 ± 4.47.09 ± 0.257.33 ± 0.176.64 ± 0.307.09 ± 0.35

  • N.C., not calculable.

  • ↵* Significantly different from virgin value.

  • ↵** EC50 are estimates because maximums may not have been obtained.