Shifts of the dose-response curves of baclofen and GHB, measured as dose ratios (95% confidence limits), produced by the GABAB antagonist CGP35348 and the GABAB receptor-positive modulators CGP7930 and rac-BHFF in different groups of pigeons trained to discriminate either baclofen or GHB from saline
p values are for the difference between the dose ratios of baclofen and GHB obtained with a particular pretreatment (Student's t test).
| Pretreatment | Treatment | Discrimination | |
|---|---|---|---|
| Baclofen vs. Saline | GHB vs. Saline | ||
| CGP35348, 100 mg/kg | Baclofen | 5.3 (3.2- 8.8)*, P = 0.10 | N.D. |
| CGP35348, 100 mg/kg | GHB | 3.0 (1.9–4.7)* | N.D. |
| CGP35348, 320 mg/kg | GHB | 3.8 (2.6–5.5)* | 2.8 (2.0–3.9)* |
| CGP7930, 100 mg/kg | Baclofen | 3.9 (2.5–6.1)*, P = 0.004 | N.D. |
| CGP7930, 100 mg/kg | GHB | 1.4 (0.8–2.4) | N.D. |
| CGP7930, 320 mg/kg | Baclofen | N.D. | 2.0 (1.2–3.3)*, P = 0.04 |
| CGP7930, 320 mg/kg | GHB | N.D. | 1.0 (0.6–1.6) |
| rac-BHFF, 32 mg/kg | Baclofen | 3.4 (2.0–5.8)*, P = 0.02 | N.D. |
| rac-BHFF, 32 mg/kg | GHB | 1.4 (0.8–2.4) | N.D. |
| rac-BHFF, 56 mg/kg | Baclofen | N.D. | 2.3 (1.2–4.3)*, P = 0.30 |
| rac-BHFF, 56 mg/kg | GHB | N.D. | 1.5 (0.9–2.4) |
N.D., not done.
↵* Dose ratio significantly different from 1.