TABLE 1

Apparent permeability (Papp) of cediranib across wild-type and MDR1-transfected MDCKII cell monolayers

Results are expressed as mean ± S.D. (n = 3–4).

Wild TypeMDR1 Transfected
A-to-BB-to-AA-to-BB-to-A
×10−4cm/s
Treatment control1.94 ± 0.102.24 ± 0.152.43 ± 0.075.0 ± 0.22*
1 μM LY3359791.17 ± 0.18†

  • ↵* P < 0.05 compared with A-B.

  • ↵† P < 0.05 compared with B-A control.