TABLE 2

Basal and reactivated mitochondrial aconitase in membrane fractions of human myocardial strips exposed to anthracyclines

Basal and reactivated mitochondrial aconitase (U/g) were measured in membrane fractions of strips incubated in plasma only (control strips) or plasma with anthracyclines at 3 or 10 μM. Values are means ± S.E. of three to seven experiments.

AconitaseControlAnthracycline
μMDoxorubicinEpirubicinAmrubicin
Basal0.41 ± 0.0230.20 ± 0.040.31 ± 0.010.33 ± 0.05
Reactivated0.78 ± 0.09*0.30 ± 0.080.50 ± 0.06*0.51 ± 0.05*
Basal0.39 ± 0.03100.26 ± 0.050.36 ± 0.090.30 ± 0.06
Reactivated0.74 ± 0.08*0.31 ± 0.070.68 ± 0.11*0.43 ± 0.09

  • ↵* Reactivated aconitase significantly higher (P < 0.01) than basal aconitase.