TABLE 2

Potency of RN486 in cell-based assays

BCR SignalingFcR Signaling
Ramos, Ca2+Human Whole Blood, CD69Mouse Whole Blood, CD69Mouse Splenocytes, CD69Mast Cells, HistamineMonocytes, TNFα
IC50, nM25.9 ± 10.9 (5)21.0 ± 1.3 (75)4.2 ± 3.2 (8)2.1 ± 0.9 (8)2.9 ± 2.3 (3)7.0 ± 2.0 (3)
  • Values are mean ± S.E.M. for the IC50 values for several experiments, with the number of experiments in parentheses.