Competitive binding IC50 values and cross-reactivity percentage
OXY(Gly)4-OVA was used as ELISA coating antigen.
| Inhibitor | IC50 | Cross-Reactivity |
|---|---|---|
| μM | % | |
| OXY(Gly)4 | 0.003 | >100 |
| OXY | 0.017 | 100 |
| Oxymorphone | 0.03 | 63 |
| Naloxone | 1 | 1.2 |
| Hydromorphone | 4 | 0.4 |
| Naltrexone | 5 | 0.4 |
| Hydrocodone | 10 | 0.2 |
| Morphine | 20 | 0.1 |
| (Gly)4 | — | |
| Methadone | — | |
| Buprenorphine | — | |
| Nicotine | — |
—, no measurable binding.