TABLE 3

Prediction of duloxetine human SERT and NET transporter occupancy by rat pharmacokinetic/pharmacodynamic modeling

EC₅₀
SERT		NET
Rat	Human	Rat	Human
ng/ml
2.32^{^a}	2.29^{^b}	47.2^{^a}	N.A.
2.95^{^c}	2.62^{^d}	59.0^{^c}
	3.7^{^e}

N.A., not available.
↵a Direct PK/PD model (current study).
↵b Direct PK/PD model (Abanades et al., 2011).
↵c Indirect (effect compartment) PK/PD model (current study).
↵d Indirect PK/PD model (Abanades et al., 2011).
↵e From Takano et al. (2006).