Overview of pharmacokinetic parameters of Lu AA21004 obtained in rats after intravenous, subcutaneous, or oral administration
| Parameter | Value |
|---|---|
| Intravenous dosing (1.5 mg/kg) | |
| CL, l · h−1 · kg−1 | 3.7 |
| Vz, l/kg | 12.7 |
| Subcutaneous dosing (2 mg/kg) | |
| Tmax, h | 0.8 |
| Cmax, nM | 281 |
| F, % | 70 |
| t1/2, h | 2.5 |
| Oral dosing (6 mg/kg) | |
| Tmax, h | 1.0 |
| Cmax, nM | 70 |
| F, % | 7 |
| t1/2, h | 3.8 |
CL, clearance; Vz, volume of distribution during terminal phase; F, bioavailability; t1/2, elimination half-life.