IC50 values of LCB 03-0110 for the inhibition of protein tyrosine kinases
| Kinase | IC50 | Kinase | IC50 |
|---|---|---|---|
| nM | nM | ||
| DDR2 | 6.0 | Syk | 25.2 |
| c-Src | 1.3 | ZAP70 | 1732 |
| Lck | 21.6 | VEGFR2 | 4.6 |
| Lyn | 4.3 | EphA3 | 5.1 |
| Fyn | 2.3 | FLT3 | 26.1 |
| Yes | 2.1 | EGFR | 273 |
| Fgr | 3.7 | IR | 10,750 |
| Hck | 4.4 | PDGFRα | 69 |
| Blk | 50.7 | PDGFRβ | 409 |
| Btk | 17.7 | c-Kit | 591.7 |
| Itk | >10,000 | FGFR1 | 827.8 |
Blk, B-cell lymphocyte kinase; Itk, IL2-inducible T-cell kinase; ZAP70, ζ-chain-associated protein kinase 70; VEGFR2, VEGF receptor 2; EGFR, endothelial growth factor receptor; IR, insulin receptor; PDGFR, PDGFR receptor; FGFR, fibroblast growth factor receptor.