TABLE 4

Influence of chronic (14 days) administration of S32212 compared with paroxetine on sexual behavior and body weight in male rats

Data are means ± S.E.M. (n = 12 per value). Number of ejaculations and latency to the first ejaculation were recorded in 30-min sessions performed at days 0, 7, 14, and day 21. Drugs or vehicle were administered daily from day 0 (acute treatment) to day 14 (chronic treatment). ANOVA results were as follows: For ejaculations, day 0, F_2,33 = 0.5, P > 0.05; day 7, F_2,33 = 36.1, P < 0.001; day 14, F_2,33 = 8.2, P < 0.01; and day 21, F_3,23 = 1.2, P > 0.05. For latency, day 0, F_2,33 = 0.3, P > 0.05; day 7, F_2,33 = 9.6, P < 0.001; day 14, F_2,33 = 6.5, P < 0.01; and day 21, F_2,33 = 1.9, P > 0.05. For body weight, day 0, F_2,33 = 0.7, P > 0.05; day 7, F_2,33 = 0.5, P > 0.05; day 14, F_2,33 = 4.0, P < 0.05; and day 21, F_2,33 = 5.2, P < 0.05.

	Day	Vehicle	Drug (Dose)
	Day	Vehicle	S32212 (2.5 mg/kg i.p.)	Paroxetine (10.0 mg/kg i.p.)
Number of ejaculations	0	1.5 ± 0.3	1.8 ± 0.3	1.9 ± 0.3
	7	2.3 ± 0.2	1.8 ± 0.2	0.3 ± 0.1^*
	14	1.9 ± 0.2	1.6 ± 0.2	0.6 ± 0.3^*
	21	1.8 ± 0.3	1.8 ± 0.4	1.1 ± 0.4
Latency (s) to the first ejaculation	0	1032 ± 179	874 ± 132	858 ± 177
	7	808 ± 112	964 ± 107	1507 ± 134^*
	14	743 ± 123	763 ± 137	1398 ± 172^*
	21	662 ± 164	851 ± 202	1195 ± 212
Body weight, g	0	418 ± 10	412 ± 7	425 ± 8
	7	428 ± 10	416 ± 7	417 ± 9
	14	435 ± 11	422 ± 7	402 ± 7^*
	21	449 ± 12	446 ± 7	412 ± 8^*

↵* , significance of differences to vehicle values in Dunnett's test after ANOVA; P < 0.05.