Controls | C+ | C+R+ | R+ | |
---|---|---|---|---|
n | 6 | 6 | 6 | 8 |
Body weight (g) | 56.68 ± 9.3 | 47.18 ± 4.5 | 32.18 ± 6.1 | 39.90 ± 2.7 |
Lung volume (cm3) | 2.89 ± 0.19 | 2.61 ± 0.26 | 2.32 ± 0.68 | 2.36 ± 0.33 |
Specific lung volume (cm3/100 g) | 5.23 ± 0.98 | 5.56 ± 0.62 | 7.09 ± 1.95 | 5.92 ± 0.73 |
Alveolar airspace | ||||
Volume density | 0.66 ± 0.03 | 0.70 ± 0.02 | 0.64 ± 0.03 | 0.67 ± 0.01 |
Absolute volume (cm3) | 1.93 ± 0.11 | 1.66 ± 0.48 | 1.49 ± 0.46 | 1.59 ± 0.22 |
Specific volume (cm3/100 g) | 3.50 ± 0.63 | 3.66 ± 0.78 | 4.54 ± 1.26 | 3.99 ± 0.47 |
Alveolar surface | ||||
Area density (cm2/cm3) | 284 ± 34 | 225 ± 27 | 230 ± 84 | 223 ± 31 |
Absolute area(cm2) | 822 ± 130 | 542 ± 193 | 520 ± 182 | 528 ± 108 |
Specific area (cm2/100 g) | 1485 ± 337 | 1187 ± 336 | 1660 ± 838 | 1320 ± 233 |
Interstitium | ||||
Volume density | 0.28 ± 0.01 | 0.25 ± 0.02 | 0.28 ± 0.05 | 0.28 ± 0.02 |
Absolute volume (cm3) | 0.82 ± 0.05 | 0.60 ± 0.19 | 0.64 ± 0.18 | 0.66 ± 0.11 |
Specific volume (cm3/100 g) | 1.48 ± 0.26 | 1.33 ± 0.31 | 2.00 ± 0.60 | 1.68 ± 0.26 |
Airways | ||||
Volume density | 0.02 ± 0.01 | 0.02 ± 0.01 | 0.03 ± 0.01 | 0.02 ± 0.01 |
Absolute volume (cm3) | 0.06 ± 0.04 | 0.04 ± 0.03 | 0.08 ± 0.05 | 0.05 ± 0.03 |
Specific volume (cm3/100 g) | 0.12 ± 0.09 | 0.10 ± 0.06 | 0.24 ± 0.15 | 0.13 ± 0.07 |
Blood vessels | ||||
Volume density | 0.02 ± 0.01 | 0.01 ± 0.01 | 0.04 ± 0.02 | 0.01 ± 0.01 |
Absolute volume (cm3) | 0.07 ± 0.02 | 0.04 ± 0.01 | 0.09 ± 0.06 | 0.04 ± 0.02 |
Specific volume (cm3/100 g) | 0.14 ± 0.05 | 0.09 ± 0.01 | 0.29 ± 0.19 | 0.11 ± 0.06 |
Data are expressed as means ± S.D. Comparison results are expressed with the F1,22 value accompanied by the corresponding p value. Body weight: infection effect F1,22 = 12.2, p = 0.0002; rolipram effect F1,22 = 27.7, p < 0.0001; interaction p > 0.05. Alveolar airspace (volume density): rolipram effect F1,22 = 11.7, p = 0.002; interaction F1,22 = 16.0, p = 0.0005. Alveolar airspace (specific volume): rolipram effect F1,22 = 4.4, p = 0.04. Interstitium (specific volume): rolipram effect F1,22 = 8.4, p = 0.008. Blood vessels (volume density): interaction only F1,22 = 6.8, p = 0.05. Blood vessels (absolute volume): interaction only F1,22 = 8.6, p = 0.007. Blood vessels (specific volume): rolipram effect F1,22 = 4.7, p = 0.04; interaction F1,22 = 7.8, p = 0.01. All other comparisons were not statistically significant.