TABLE 3

Anxiolytic properties of S32212 in the Vogel conflict test in rats

Data are means ± S.E.M. (n = 4–10 per value). ANOVA results for punished groups were: F4,37 = 5.4; P < 0.01.

RatsDoseNumber of Licks
NonpunishedVehicle672 ± 75
PunishedVehicle79 ± 17#
S32212 0.63 mg/kg i.p.97 ± 34
S32212 2.5 mg/kg i.p.193 ± 55
S32212 10.0 mg/kg i.p.433 ± 106*
S32212 40.0 mg/kg i.p.528 ± 110*

  • ↵# , significance of differences to vehicle nonpunished value in Student's t test.

  • ↵* , significance of differences to vehicle values in Dunnett's test; P < 0.05.