TABLE 2

Effects of LAF237 on renal function in nondiabetic and diabetic rats

Data are expressed as mean ± S.E.M.

	Week	Group
	Week	nonDM	nonDM + 8LAF	DM	DM + 4LAF	DM + 8LAF
Serum creatinine, mg/dl	12	0.48 ± 0.03	0.44 ± 0.02	0.96 ± 0.07^{^a}	0.69 ± 0.07^{^b}	0.67 ± 0.07^{^b}
	24	0.47 ± 0.01	0.51 ± 0.02	1.31 ± 0.11^{^a}	0.75 ± 0.03^{^c}	0.62 ± 0.02^{^c}
Blood urea nitrogen, mg/dl	12	25.2 ± 1.47	24.5 ± 1.25	52.7 ± 3.19^{^a}	43.4 ± 2.34^{^b}	41.4 ± 3.15^{^b}
	24	30.5 ± 0.59	28.5 ± 0.61	65.5 ± 2.31^{^a}	46.3 ± 1.03^{^c}	52.6 ± 0.99^{^c}
Urinary albumin, μg	12	251 ± 22	244 ± 24	944 ± 79^{^a}	701 ± 68^{^b}	677 ± 63^{^b}
	24	257 ± 69	249 ± 77	1410 ± 99^{^a}	1006 ± 85^{^b}	801 ± 36^{^c}
Urinary protein, mg	12	11.1 ± 1.3	12.7 ± 1.5	19.9 ± 1.4^{^d}	14.2 ± 1.1^{^b}	14.3 ± 1.4^{^b}
	24	13.1 ± 1.1	14.4 ± 0.9	24.5 ± 1.8^{^d}	15.1 ± 1.4^{^c}	17.0 ± 1.3^{^c}
Albumin, μg/creatinine, mg	12	14.8 ± 1.1	15.7 ± 1.3	65.7 ± 5.4^{^a}	44.2 ± 3.4^{^b}	40.7 ± 3.8^{^b}
	24	16.1 ± 1.2	17.4 ± 1.1	88.1 ± 4.6^{^a}	64.8 ± 3.1^{^c}	60.0 ± 2.8^{^c}
Creatinine clearance, ml/min	12	1.98 ± 0.28	2.04 ± 0.19	0.87 ± 0.09^{^d}	1.25 ± 0.11^{^b}	1.28 ± 0.12^{^b}
	24	1.92 ± 0.20	1.86 ± 0.22	0.73 ± 0.07^{^d}	1.16 ± 0.10^{^c}	1.30 ± 0.12^{^c}

↵a P < 0.01 compared with nonDM.
↵b P < 0.05 compared with DM.
↵c P < 0.01 compared with DM.
↵d P < 0.05 compared with nonDM.