Pharmacokinetic parameters of DM-CocE
Each condition is n = 3. Mean ± S.D. is in parentheses.
| Western Blot Estimation | Normal | Unilateral Nephrectomy | |
|---|---|---|---|
| Glomerular filtration rate, μl/min | 6030 (106.4) | 2610 (53.4)* | |
| Urine output, total 29 h | 13.0 (1.8) | 15.2 (6.3) n/s | |
| Weight | 343.3 (31.75) | 302.0 (10.82) n/s | |
| AUC, μg/ml/min | 14,461 (7445) | 14,932 (606.8) n/s | |
| Clearance, ml/min | 0.12 | 0.21 (0.07) | 0.16 (0.01) n/s |
| Vd, ml | 24.6 | 38.1 (11.4) | 36.6 (5.4) n/s |
| t1/2, min | 144 | 125 (6.8) | 156 (19.8) n/s |
↵* , p < 0.001 Student's t test compared with normal.
n/s, p > 0.05 Student's t test compared with normal.