ED50 values and 95% CLs for rimonabant, alone and in combination with Δ9-THC, JWH-018, and JWH-073, in Δ9-THC (1 mg/kg/12 h)-treated rhesus monkeys discriminating rimonabant (1 mg/kg i.v.)
Potency ratios and 95% CLs are the ED50 values of rimonabant in combination with the agonist divided by the ED50 value of rimonabant alone.
| Drug | ED50 Value (95% CL) | Potency Ratio (95% CL) |
|---|---|---|
| mg/kg | ||
| Rimonabant | 0.20 (0.14–0.29) | |
| + Δ9-THC (1 mg/kg) | 0.59 (0.53–0.66)* | 2.9 (1.9–4.4) |
| + Δ9-THC (3.2 mg/kg) | 1.7 (0.84–3.5)* | 8.5 (4.5–16) |
| + Δ9-THC (10 mg/kg) | 5.8 (0.93–52)* | 29 (17–70) |
| + JWH-018 (0.32 mg/kg) | 0.63 (0.41–0.97)* | 3.1 (1.9–5.0) |
| + JWH-018 (1 mg/kg) | 2.2 (1.2–4.1)* | 11 (6.1–20) |
| + JWH-018 (3.2 mg/kg) | 5.7 (2.5–13)* | 29 (16–50) |
| + JWH-073 (3.2 mg/kg) | 0.40 (0.14–1.2) | 2.0 (0.9–4.0) |
| + JWH-073 (10 mg/kg) | 1.3 (1.2–1.6)* | 6.5 (4.3–10) |
| + JWH-073 (32 mg/kg) | 2.1 (1.2–3.7)* | 11 (6.0–17) |
↵* Significantly different from rimonabant alone.