TABLE 6

Effect of CEP-26401 on sleep latencies and motor activity after oral dosing

Mean ± S.E.M. (n = 6–10 per group).

ParameterVehicleCEP-26401
3 mg/kg10 mg/kg30 mg/kg
SWS latency, mina32.9 ± 4.238.1 ± 5.482.7 ± 17.7*216.7 ± 23.0*
REMS latency, mina42.5 ± 3.586.0 ± 27.9113.9 ± 13.2281.6 ± 44.9*
Motor activityb4.74 ± 1.305.47 ± 0.726.93 ± 1.167.92 ± 1.38
Motor intensityc2.94 ± 0.752.73 ± 0.522.28 ± 0.352.37 ± 0.36

  • ↵a P < 0.05, ANOVA for treatment (* P < 0.05 vs. vehicle by Dunnett's test).

  • ↵b Cumulative motor activity for 4 h postdosing, arbitrary units.

  • ↵c Motor intensity = (average motor activity units for 2 h postdosing)/(average EEG wake time (h) for 2 h postdosing).