TABLE 3

Correlation of Rac-6-, R-6-, and S-6-hydroxywarfarin glucuronidation rates with UGT probe activities and immunoquantified protein measured in a bank of 50 human liver microsomes

UGT Isoform	Probe	Rac-6-hydroxywarfarin Glucuronidation		R-6-Hydroxywarfarin Glucuronidation		S-6-Hydroxywarfarin Glucuronidation
UGT Isoform	Probe	Spearman R Value	p Value	Spearman R Value	p Value	Spearman R Value	p Value
UGT1A1	Bilirubin	0.722	0.0000002	0.69	0.0000002	0.685	0.0000002
UGT1A4	Trifluoperazine	0.491	0.000324	0.56	0.0000269	0.475	0.000546
UGT1A6	Serotonin	0.592	0.00000842	0.597	0.00000668	0.508	0.000217
UGT1A9	Propofol	0.643	0.00000151	0.617	0.00000653	0.543	0.000132
UGT2B7	Zidovudine	−0.0926	0.521	−0.135	0.349	−0.0661	0.647
UGT2B15	S-Oxazepam	0.447	0.00121	0.364	0.00952	0.451	0.00108
UGT1A1	Protein	0.674	1.53 × 10⁻⁸	0.668	1.34 × 10⁻⁷	0.664	0.00000141
UGT1A6	Protein	0.422	0.00328	0.437	0.00224	0.325	0.0262
UGT1A9	Protein	0.353	0.0176	0.34	0.0224	0.232	0.124
UGT2B7	Protein	−0.275	0.0535	−0.282	0.0471	−0.196	0.171