TABLE 1

Body weight, nonfasting blood glucose levels, daily food and water intake, and AUC from OGTTa in control, diabetic (STZ), and diabetic rats treated with PKF275–055 under the protection or prevention schedules at day 35 after STZ injection

Results are means ± S.E.M.

GroupBody WeightBlood GlucoseFood IntakeWater IntakeOGTT AUC
gmMgmlmM × min
Control406 ± 8.14.7 ± 0.1227 ± 0.830 ± 2.9115 ± 12.2*
Control + PKF411 ± 8.44.7 ± 0.1827 ± 0.942 ± 1.8115 ± 10.6*
STZ untreated253 ± 11.9**22.2 ± 1.33**44 ± 3.3***265 ± 15.3**243. ± 42.6
STZ + PKF protection273 ± 13.0**21.9 ± 2.32**43 ± 2.6***232 ± 17.1**98 ± 13.8*
STZ + PKF prevention247 ± 21.7**19.0 ± 1.52**43 ± 4.5***265 ± 14.2**167 ± 27.8
  • * P < 0.005 vs. STZ untreated.

  • ** P < 0.001 vs. CTRL and CTRL + PKF.

  • *** P < 0.001 vs. CTRL and CTRL + PKF.