Compound | In Vitro Aβ42 IC50 | Projected Human Free Brain Concentration Causing 50% Inhibition of Generation of | PK/PD Modeling-Derived Free Brain Concentration in 129/SVE Mouse Causing 50% Inhibition of Generation of CSF Aβx-40 | |
---|---|---|---|---|
CSF Aβ1–40 | CSF Aβ1–42 | |||
nM | ||||
BMS-708163 | 0.34 | 17 | 12 | 21 |
LY450139 | 3.3 | 339 | 550 | 192 |