Parameter | LY450139 | BMS-708163 | |||
---|---|---|---|---|---|
CSF Aβ40 | CSF Aβ42 | CSF Aβ1-x | CSF Aβ40 | CSF Aβ42 | |
Imax | 0.71 | 0.65 | 1 | 1 (fixed) | 1 (fixed) |
γ | 2.91 | 3.55 | 1 | 2.60 (0.68) | 1.91 (0.31) |
kout, 1/h | 0.12 | 0.10 | 0.13 | 0.05 (0.01) | 0.09 (0.01) |
IC50, CSF concentration, nM | 313 | 493 | 479 | 3.9 (0.3) | 2.7 (0.2) |
IC50, free brain concentration estimated, nM | 250.4 | 394.4 | 383.2 | 17.1 (1.4) | 11.9 (0.7) |