TABLE 5

Comparison of simulated human PK parameters and the parameters from human subjects after 20-mg oral dose

Parameter	Predicted	Healthy Male after 20-mg Oral Dose^{^a}	AZD3783 Human PET Study at 20-mg Oral Dose^{^b}
T_max, h	1.4	2.5 (1.5, 3)	2, 3, 3
T_1/2, h	13	17 (12, 36)	7.3, 10.7, 12.2
AUC_0-inf, nM/h	1853	1018 (224%)	761, 977, 2684
C_max, nM	90	79 (21%)	54, 80, 182
C_min, nM	23	N.D.	N.D.
Vd_ss, l/kg	6.4	N.D.	N.D.
CL, l/h/kg^{^c}	0.39	0.60 (19%)	N.D.

N.D., not determined.
↵a n = 6, values are presented as median (minimum, maximum) value for T_max and t_1/2, geometric mean (CV%) for AUC and C_max.
↵b Data are from Varnäs et al. (2011).
↵c CL data from clinical observation are presented as geometric mean of oral clearance, CL/F (CV%).