Species | Route | Dose | Cmax | Tmaxa | AUC∞ | CLplasma | Vdss | t1/2 | F |
---|---|---|---|---|---|---|---|---|---|
μmol/kg | μM | h | μM/h | ml/min/kg | l/kg | h | % | ||
Rat | IV | 10 | N.D. | N.D. | 8.8 ± 0.9 | 19 ± 2.8 | 2.3 ± 0.2 | 1.4 ± 0.3 | N.D. |
PO | 30 | 9.5 ± 3.80 | 0.25 | 26 ± 6.0 | N.D. | N.D. | N.D. | 98 | |
Dog | IV | 2.0 | N.D. | N.D. | 1.9 ± 0.1 | 18 ± 0.9 | 4.3 ± 0.4 | 3.7 ± 0.5 | N.D. |
PO | 2.0 | 0.24 ± 0.01 | 1.00 | 1.1 ± 0.1 | N.D. | N.D. | N.D. | 58 | |
Monkey | IV | 3.0 | N.D. | N.D. | 1.5 ± 0.1 | 35 ± 0.8 | 5.9 ± 0.8 | 4.6 ± 0.6 | N.D. |
IV, intravenous; PO, oral; N.D., not determined.
↵a Median number.