TABLE 2

Results of statistical analysis of the effects of drug combinations on cocaine self-administration

Treatment	Cocaine Dose	Pretreatment	Interaction	Post Hoc Test
Treatment	Cocaine Dose	Pretreatment	Interaction	At 0.1 mg/kg per Injection Cocaine	At 0.32 mg/kg per Injection Cocaine
0.1 mg/kg WIN 35,428 and BD 1008	F_4,40 = 6.38, p = 0.002	F_2,40 = 4.51, p = 0.040	F_8,40 = 3.57, p = 0.003	N.S.	10 mg/kg BD 1008, t = 5.84, p < 0.001
0.1 mg/kg WIN 35,428 and BD 1047	F_4,40 = 21.8, p < 0.001	F_2,40 = 1.22, p = 0.337	F_8,40 = 1.94, p = 0.081	N.S.	N.S.
0.1 mg/kg WIN 35,428 and BD 1063	F_4,40 = 4.15, p = 0.013	F_2,40 = 0.601, p = 0.567	F_8,40 = 0.63, p = 0.748	N.S.	N.S.
0.3 mg/kg WIN 35,428 and BD 1008	F_4,80 = 6.91, p = 0.001	F_4,80 = 5.68, p = 0.003	F_16,80 = 4.62, p < 0.001	1.0 mg/kg BD 1008, t = 3.00, p = 0.034	0.32–10 mg/kg BD 1008, t = 5.50, 5.59, 5.62, and 6.12, respectively, p <0.001
0.3 mg/kg WIN 35,428 and BD 1047	F_4,80 = 11.8, p < 0.001	F_4,80 = 1.65, p = 0.201	F_16,80 = 2.97, p < 0.001	0.32 mg/kg BD 1047, t = 4.03, p ≤ 0.002	N.S.
				1.0 mg/kg BD 1047, t = 3.90, p ≤ 0.002
0.3 mg/kg WIN 35,428 and BD 1063	F_4,80 = 14.2, p < 0.001	F_4,80 = 3.33, p = 0.030	F_16,80 = 4.54, p < 0.001	0.32 mg/kg BD 1063, t = 6.09, p ≤ 0.009	N.S.
				1.0 mg/kg BD 1063, t = 3.42, p ≤ 0.009
1.0 mg/kg MPD and BD 1008	F_4,60 = 8.54, p < 0.001	F_3,60 = 8.06, p = 0.002	F_12,60 = 7.27, p < 0.001	3.2 mg/kg BD 1008, t = 3.15, p ≤ 0.016	3.2 mg/kg BD 1008, t = 4.54, p < 0.001
				10 mg/kg BD 1008, t = 4.37, p ≤ 0.016	10 mg/kg BD 1008, t = 6.62, p < 0.001
1.0 mg/kg MPD and BD 1047	F_4,60 = 8.41, p < 0.001	F_3,60 = 8.98, p = 0.001	F_12,60 = 7.10, p < 0.001	3.2 mg/kg BD 1047, t = 4.44, p < 0.001	3.2 mg/kg BD 1047, t = 5.99, p < 0.001
				10 mg/kg BD 1047, t = 4.31, p < 0.001	10 mg/kg BD 1047, t = 7.02, p < 0.001
1.0 mg/kg MPD and BD 1063	F_4,60 = 8.99, p < 0.001	F_3,60 = 8.77, p = 0.001	F_12,60 = 7.56, p < 0.001	3.2 mg/kg BD 1063, t = 4.24, p < 0.001	3.2 mg/kg BD 1063, t = 5.64, p < 0.001
				10 mg/kg BD 1063, t = 4.37, p < 0.001	10 mg/kg BD 1063, t = 6.99, p < 0.001
0.32 mg/kg nomifensine and BD 1008	F_4,60 = 14.7, p < 0.001	F_3,60 = 13.7, p < 0.001	F_12,60 = 12.8, p < 0.001	3.2 mg/kg BD 1008, t = 6.11, p < 0.001	3.2 mg/kg BD 1008, t = 7.35, p < 0.001
				10 mg/kg BD 1008, t = 5.91, p < 0.001	10 mg/kg BD 1008, t = 9.00, p < 0.001
0.32 mg/kg nomifensine and BD 1047	F_4,60 = 13.3, p < 0.001	F_3,60 = 12.9, p = 0.001	F_12,60 = 11.8, p < 0.001	3.2 mg/kg BD 1047, t = 4.63, p < 0.001	3.2 mg/kg BD 1047, t = 5.26, p < 0.001
				10 mg/kg BD 1047, t = 5.77, p < 0.001	10 mg/kg BD 1047, t = 8.26, p < 0.001
0.32 mg/kg nomifensine and BD 1063	F_4,60 = 16.3, p < 0.001	F_3,60 = 14.9, p = 0.001	F_12,60 = 13.3, p < 0.001	3.2 mg/kg BD 1063, t = 6.19, p < 0.001	3.2 mg/kg BD 1063, t = 7.31, p < 0.001
				10 mg/kg BD 1063, t = 6.30, p < 0.001	10 mg/kg BD 1063, t = 9.22, p < 0.001

N.S., not significant.