Prediction Method | Parameter Sourcea | F | Vdss | CL | t1/2 |
---|---|---|---|---|---|
% | l/kg | ml/min/kg | h | ||
In vitro scaling | CL human liver microsome and hepatocyte | 70 | N.D. | 6.5b (5.1–7.9) | N.D. |
Allometry | CL, Vdss from rat, dog, and monkey; ka from dog | 0 | 7.5 (exponent 1.190 > 1.0) | 25 (exponent 1.023 > 0.75) | 3 |
Single-species scaling, dog | Vdss and CL from dog | 0 | 7.4 | 19 | 4 |
Single-species scaling, dog | Vdss from dog, CL from human liver microsome/human hepatocyte | 70 | 7.4 | 6.5 (5.1–7.9) | 13 (11–17) |
Oie-Tozer equation | Rat, dog, and monkey PK parameters | N.D. | 4.2 | N.D. | N.D. |