TABLE 1

TAK-875 enhances intracellular inositol monophosphate production in INS-1 833/15 cells

Data are mean ± S.D. (n = 3).

CompoundIntracellular Inositol Monophosphate Concentration
1 mM Glucose3 mM Glucose10 mM Glucose
nM
Vehicle153.9 ± 14.7151.8 ± 8.8161.5 ± 15.1
TAK-875, 0.1 μM226.0 ± 19.3a236.7 ± 31.7a239.9 ± 14.2a
TAK-875, 1 μM436.2 ± 30.9a478.4 ± 30.7a415.5 ± 80.8a
TAK-875, 10 μM486.0 ± 38.5a521.2 ± 67.3a464.2 ± 13.1a
Glibenclamide, 10 μM143.4 ± 19.2134.5 ± 16.7128.8 ± 12.2
  • a P ≤ 0.025 vs. control (vehicle with each respective glucose concentration) by one-tailed Williams' test.