TABLE 1

AEA and 2-AG levels in brain regions and ileum are not altered after treatment with either morphine or placebo and acute challenge with either saline or naloxone (1 mg/kg s.c.)

Data are expressed as means ± S.E.M.

TreatmentAEA Levels2-AG Levels
LCPAGAmygdalaIleumLCPAGAmygdalaIleum
pmol/gnmol/g
Placebo-saline3.7 ± 0.34.2 ± 0.39.5 ± 0.81.2 ± 0.36.4 ± 0.411.1 ± 0.911.6 ± 1.35.6 ± 0.7
Morphine-saline5.1 ± 1.04.5 ± 0.68.2 ± 0.61.3 ± 0.27.0 ± 0.511.8 ± 1.510.8 ± 0.95.6 ± 1.1
Placebo-naloxone4.7 ± 0.44.8 ± 0.59.1 ± 1.11.5 ± 0.16.9 ± 0.711.7 ± 2.417.7 ± 4.25.8 ± 1.0
Morphine-naloxone4.3 ± 0.44.6 ± 0.58.2 ± 0.61.7 ± 0.26.3 ± 0.610.2 ± 0.817.0 ± 3.66.6 ± 1.9