List of doses administered to rats and serum concentration goals
| SRI | Dose | Desired Serum Concentration | Measured Serum Compound | ||
|---|---|---|---|---|---|
| Median | High | 50th | 85th | ||
| mg/kg/day | ng/ml | ||||
| Sertraline | 7 | 10 | 25/50 | 100/150 | Sertraline/DMS |
| Paroxetine | 3 | 8 | 80 | 160 | Paroxetine |
| Fluoxetine | 8 | 11–12 | 300–400 | 800–1100 | Fluoxetine + norfluoxetine |
| Venlafaxine | 50–60 | 70–80 | 300–400 | 800–1100 | Venlafaxine + ODV |
| Escitalopram | 4.3–4.9 | 10.2–11.8 | 20 | 60 | Escitalopram |
DMS, desmethylsertraline; ODV, O-desmethylvenlafaxine.