TABLE 1

siRNAs

Control siRNAs (C2, C3) contain four or more mismatches with all known human RNAs.

siRNATargeted RNATarget mRNA SequencePosition in mRNA Transcript
ON-TARGETplus Nontargeting siRNA C2No target5′-UGGUUUACAUGUUGUGUGA-3′
ON-TARGETplus Nontargeting siRNA C3No target5′-UGGUUUACAUGUUUUCUGA-3′
TYMS siGENOME siRNA, TS siRNA(1)TS mRNA5′-ACAGAGAUAUGGAAUCAGA-3′576–594 Coding region
TYMS siGENOME siRNA, TS siRNA(2)TS mRNA5′-GGACUUGGGCCCAGUUUAU-3′526–544 Coding region
Human TK1 ON-TARGETplus siRNA, TK1 siRNA(1)TK1 mRNA5′-GCACAGAGUUGAUGAGACG-3′308–326 Coding region
Human TK1 ON-TARGETplus siRNA, TK1 siRNA(2)TK1 mRNA5′-CAAAGACACUCGCUACAGC-3′578–596 Coding region
Human TK2 ON-TARGETplus siRNA, TK2 siRNA(1)TK2 mRNA5′-AAAUCGGGAUCGAAUAUUA-3′1101–1119 Coding region
Human TK2 ON-TARGETplus siRNA, TK2 siRNA(2)TK2 mRNA5′-UCACAGCGCAAGAUACAUU-3′759–777 Coding region