Pharmacodynamic parameter estimates of PF04942847 for AKT degradation in athymic mice bearing MDA-MB-231 tumors (model I)
Precision of the estimates is expressed as S.E. in parentheses.
| Parameter | Estimate |
|---|---|
| E0 | 1 (fixed) |
| Emax | 0.91 (0.12) |
| EC50, ng/ml | 18 (9.3) |
| ke0, h−1 | 0.012 (0.056) |
| γ | 1.1 (0.27) |
| obj | −360 |