TABLE 1

Effect of inhalation of unmodified SOD on PPE-induced pulmonary emphysema

Mice were treated with a single dose of PPE (50 μg/mouse) at day 0 and inhaled unmodified SOD (U-SOD; 600 kU/chamber) once daily for 3 days (days 0–2). Inflammatory response and the mean linear intercept were assessed as described in the legend of Fig. 1. Values are mean ± S.E.M.

PPE (50) (n = 8)+ U-SOD (600 kU/chamber) (n = 4)
Total cells, ×1054.9 ± 0.334.9 ± 0.35
Alveolar macrophages, ×1054.7 ± 0.364.7 ± 0.33
Lymphocytes, ×1040.40 ± 0.070.35 ± 0.06
Neutrophils, × 1041.6 ± 0.151.3 ± 0.19
Mean linear intercept, μm58.2 ± 1.3057.7 ± 0.37