TABLE 5

IC₅₀ Values and maximal inhibition

Maximum percentage inhibition is defined as inhibition observed for 1000 nM of dexamethasone or BIRB-796. Maximum percentage inhibition data are presented as mean (S.D.).

	IC₅₀			Maximum Percentage Inhibition
	HNS	Smokers	COPD	HNS	Smokers	COPD	P Value
Dexamethasone
IL-8	45.7	11.0	29.5	53.6 (15.4)	59.1 (22.9)	60.5 (11.1)	0.70
IL-6	11.8	6.3	8.1	65.9 (21.9)	80.5 (11.7)	75.3 (11.8)	0.26
TNF-α	7.6	9.8	5.3	82.2 (9.1)	80.2 (9.8)	83.9 (7.9)	0.72
GM-CSF	2.6	3.8	2.3	85.8 (10.5)	89.0 (8.2)	83.9 (11.7)	0.66
IL-1α	N.C.	N.C.	N.C.	N.C.	38.6 (29.6)	23.3 (55.0)	N.C.
IL-1β	N.C.	N.C.	N.C.	7.8 (100)	23.2 (32.3)	49.2 (32.5)	0.37
IL-1ra	3.2	3.8	7.1	80.9 (7.0)	85.4 (4.8)	83.7 (9.0)	0.62
IL-10	2.6	2.5	3.8	90.0 (9.0)	89.5 (13.1)	87.8 (10.9)	0.92
MCP-3	4.9	6.3	9.1	70.6 (15.5)	77.8 (17.1)	79.7 (10.3)	0.45
MDC	N.C.	N.C.	N.C.	43.0 (28.9)	34.3 (32.9)	37.0 (31.2)	0.88
RANTES	14.1	33.1	13.2	63.7 (7.9)	63.1 (9.3)	54.4 (19.7)	0.39
BIRB-796
IL-8	N.C.	N.C.	N.C.	34.0 (16.8)	27.7 (28.5)	31.2 (25.9)	0.91
IL-6	N.C.	N.C.	N.C.	52.4 (12.0)	55.3 (22.4)	46.1 (11.8)	0.48
TNF-α	N.C.	N.C.	N.C.	70.5 (7.3)	52.2 (20.8)	64.6 (9.0)	0.065
GM-CSF	3.6	331.1	N.C.	74.4 (10.5)	55.1 (24.4)	49.3 (20.7)	0.068
IL-1α	N.C.	N.C.	N.C.	N.C.	40.5 (36.8)	28.5 (30.8)	N.C.
IL-1β	114.8	N.C.	N.C.	82.5 (5.4)	N.C.	10.0 (65.7)	N.C.
IL-1ra	47.9	95.5	190.6	57.2 (6.5)	60.1 (10.6)	53.0 (23.0)	0.72
IL-10	N.C.	N.C.	N.C.	N.C.	N.C.	N.C.	N.C.
MCP-3	N.C.	N.C.	N.C.	19.2 (75.7)	N.C.	2.4 (57.7)	N.C.
MDC	11.6	27.5	38.0	79.0 (21.1)	77.4 (19.4)	75.9 (18.7)	0.82
RANTES	N.C.	N.C.	N.C.	47.2 (6.8)	33.8 (19.4)	26.8 (23.5)	0.15

N.C., not able to calculate IC₅₀ from the curve.