TABLE 3

PI metabolite levels in mouse tissues 1 h after oral administration of 400 mg/kg PI

Experiments were done independently three times; values were generally within 15%.

PI1-OH-PICarboxyl-PIIbuprofen1-OH-Ibuprofen2-OH-IbuprofenCarboxyl-IbuprofenIbuprofen Glucuronide
pmol/mg protein
Liver82221013739193313408
Heart101N.D.N.D.24093496N.D.55
Kidney121N.D.N.D.194675220104322
Stomach421N.D.N.D.462N.D.N.D.N.D.N.D.
Small intestine521N.D.36913N.D.N.D.N.D.50
Colon414N.D.20431N.D.N.D.N.D.64
Blood*N.D.N.D.N.D.530246010121

  • N.D., not detected.

  • ↵* Metabolite levels in the blood were expressed as μM in plasma.