TABLE 1

Pharmacokinetic parameters of TAK-438F in rats and dogs given a single oral and intravenous dose of [14C]TAK-438 or TAK-438

Data show mean value ± S.E. (rats, n = 3; dogs, n = 4) except BA (mean). The Cmax after intravenous administration denotes the C5min.

Dosing RouteDoseTmaxCmaxt1/2AUCconcBA
mg/kghng/mlhng · h/ml%
RatOral20.3 ± 0.017 ± 31.3 ± 0.127 ± 310
Intravenous0.7560 ± 61.2 ± 0.099 ± 4
DogOral0.31.0 ± 0.030 ± 61.1 ± 0.168 ± 1652
Intravenous0.126 ± 21.2 ± 0.144 ± 2