Effect of SLx-4090 on serum levels of vitamins E, A, and C in Male Sprague-Dawley rats
Values are the mean ± S.E.M. of the number of animals shown in parentheses and are reported as μg/ml. There were no significant differences among groups or treatments on any measure.
| Dose Regimen | Four Daily Doses | 14 Daily Doses | ||||
|---|---|---|---|---|---|---|
| Vehicle | SLx-4090 (30 mg/kg) | CP-346086 (30 mg/kg) | Vehicle | SLx-4090 (30 mg/kg) | CP-346086 (30 mg/kg) | |
| μg/ml | ||||||
| Vitamin E | 1.27 ± 0.17 (4) | 1.49 ± 0.16 (5) | 0.94 ± 0.13 (4) | 2.11 ± 0.91 (2) | 1.61 ± 0.23 (4) | 1.14 ± 0.09 (4) |
| Vitamin A | 0.76 ± 0.09 (4) | 0.76 ± 0.05 (5) | 0.68 ± 0.08 (4) | 0.68 ± 0.00 (2) | 0.75 ± 0.08 (4) | 0.92 ± 0.13 (4) |
| Vitamin C | 2.73 ± 0.34 (5) | 2.78 ± 0.25 (5) | 2.60 ± 0.33 (5) | N.D. | N.D. | N.D. |
N.D., not determined.