In vitro enzyme kinetics of PR-104A glucuronidation (estimate ± S.E.)
| Mouse | Rat | Dog | Human | rUGT2B7 | |
|---|---|---|---|---|---|
| Km (μM) | 155.4 ± 13.7 | 97.4 ± 6.2 | 157.1 ± 7.6 | 178.2 ± 11.9 | 63.4 ± 3.4 |
| Vmax(nmol/min/mg) | 0.24 ± 0.01 | 0.61 ± 0.01 | 7.87 ± 0.17 | 1.47 ± 0.05 | 0.58 ± 0.01 |
| CLint (μl/min/mg) | 1.54 | 6.26 | 50.1 | 8.25 | — |