Potency values (LogEC50) for R-568 and calcimimetic B to the hCaSR in FLIPR, aequorin, and inositol phosphate accumulation assays
Parameter values were obtained by nonlinear regression analysis using the variable slope Hill equation as described under Materials and Methods. Values represent the mean ± S.D.
| Log EC50 | ||
|---|---|---|
| R-568 | Calcimimetic B | |
| Ca2+ flux (FLIPR) | −7.2 ± 0.14 (n = 9) | −8.1 ± 0.35 (n = 37)* |
| Ca2+ flux (aequorin) | −6.4 ± 0.10 (n = 3) | −7.8 ± 0.14 (n = 9)* |
| IP accumulation | −6.4 ± 0.13 (n = 33) | −7.7 ± 0.15 (n = 32)* |
↵* Significantly different compared with R-568, P < 0.001 (t test).