Characteristics of spontaneous GABAergic PSCs recorded in the presence and absence of kynurenine (200 μM) from CA1 SRIs in hippocampal slices from preweaned (P10) and postweaned (P30) rats
Recordings were obtained from neurons in slices incubated for 2 to 7 h in kynurenine-free (control) and kynurenine (200 μM)-containing ACSF. Data are presented as the mean ± S.E.M. of results obtained from the number of neurons presented in parentheses.
| P10 | P30 | |||
|---|---|---|---|---|
| Control (n = 8) | Kynurenine (n = 9) | Control (n = 6) | Kynurenine (n = 10) | |
| Frequency (Hz) | 0.69 ± 0.14 | 0.92 ± 0.18 | 1.42 ± 0.19 | 1.43 ± 0.21 |
| Peak amplitude (pA) | 22.7 ± 1.03 | 21.2 ± 1.50 | 32.6 ± 2.90 | 26.9 ± 1.50 |
| Rise time (10–90%, ms) | 2.60 ± 0.37 | 2.55 ± 0.20 | 1.63 ± 0.26 | 2.02 ± 0.30 |
| Decay-time constant (ms) | 33.7 ± 1.76 | 33.1 ± 1.91 | 23.3 ± 2.18 | 24.7 ± 1.80 |