Fibronectin Deposition | Mitochondrial Activity | VEGF | IL-6 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pan | α | β | δ | Pan | α | β | δ | Pan | α | β | δ | Pan | α | β | δ | |
Nonasthmatic ASM | ↓ | ↓ | x | x | x | x | x | x | x | ↓ | ↓ | x | x | ↓ | ↓ | x |
Asthmatic ASM | ↓ | ↓ | x | x | ↓ | ↓ | x | x | x | ↓ | x | x | x | ↓ | ↓/x | x |
Lung fibroblasts | ↓ | ↓ | x | x | ↓ | ↓ | x | x | x | ↓ | ↓ | x | x | ↓ | ↓ | ↓ |
↓, inhibitory effect of isoform-specific inhibitor; x, no significant effect.