Resistance to ixabepilone conferred by P-gp in the absence or presence of inhibitors in transfected MDCK cells
Data are reported as mean (n = 8).
| Inhibitor | IC50 | |
|---|---|---|
| MDCK | MDCK-MDR1 | |
| nM | ||
| No inhibitor (ixabepilone only) | 60.4 | 1443 |
| GF120918 (1 μM) | 15.7 | 16.0 |
| Cyclosporin A (2.5 μg/ml) | 23.4 | 26.3 |
| Verapamil (10 μM) | 24.7 | 80.8 |
| FTC (5 μM) | 52.0 | 814 |
| MK-571 (50 μM) | 51.8 | 1678 |