Analog | EC50 | Calcium Flux (% Ionomycin) | |||
---|---|---|---|---|---|
2 μM | 20 μM | 100 μM | 200 μM | ||
μM | |||||
Nonivamide | 1.4 | 15 ± 3* | 24 ± 7* | 20 ± 9 | 21 ± 9* |
N-Benzylnonanamide | —a | N.D. | N.D. | N.D. | N.D. |
N-(3-Methoxybenzyl)nonanamide | — | N.D. | N.D. | N.D. | N.D. |
N-(3,4-Dimethoxybenzyl)nonanamide | 120 | N.D. | N.D. | 6 ± 4 | 7 ± 3 |
N-(3-Hydroxy-4-methoxybenzyl)nonanamide | 70 | N.D. | N.D. | 6 ± 4 | 6 ± 4 |
N-(3,4-Dihydroxybenzyl)nonanamide | 10.0 | N.D. | 18 ± 4* | 19 ± 5 | 19 ± 3* |
3-Methoxy-4-(nonamidomethyl)phenyl sulfate | 470 | N.D. | 4 ± 1 | 5 ± 3 | 9 ± 7 |
N-(4-Trifluoromethylbenzyl)nonanamide | — | N.D. | N.D. | N.D. | N.D. |
N-(4-Hydroxybenzyl)nonanamide | — | N.D. | N.D. | 2 ± 1 | 2 ± 1 |