Pharmacokinetic profile of sydnocarb compared with d-AMPH
Values represent group means ± S.E.M. of the pharmacokinetic parameters of sydnocarb (10 and 30 mg/kg i.p., n = 6) and d-AMPH (0.3 and 1.0 i.p., n = 3–4).
| Sydnocarb | d-AMPH | |||
|---|---|---|---|---|
| 10 mg/kg | 30 mg/kg | 0.3 mg/kg | 1 mg/kg | |
| Cmax (ng/ml) | 1030 ± 120 | 3460 ± 460 | 47.8 ± 6.8 | 266 ± 24 |
| tmax (h) | 0.38 ± 0.12 | 1.33 ± 0.21 | 0.38 ± 0.07 | 0.31 ± 0.06 |
| AUC0−t (ng · h−1 · ml−1) | 3100 ± 430 | 13,600 ± 2000 | 63.7 ± 6.4 | 461 ± 59 |
| t1/2 (h) | 2.29 ± 0.17 | 2.42 ± 0.12 | 1.04 ± 0.04 | 0.88 ± 0.06 |
| B/P (1 h) | 1.39 ± 0.04 | 1.48 ± 0.11 | 7.72 ± 0.22 | 7.20 ± 0.95 |
| B/P (6 h) | 1.22 ± 0.09 | 1.15 ± 0.09 | N.A. | N.A. |
AUC0−t, area under the curve until 6 h after dosing; B/P (1 h) and B/P (6 h), ratios of brain-to-plasma concentrations at 1 and 6 h after injection, respectively; N.A., not available because of concentrations of d-AMPH below the MQL of 5 ng/ml and 15 ng/g in the plasma and brain, respectively.