Developmental changes in regional density and affinity of D2-like dopamine receptors
Data are presented as the mean ± S.E.M. (n = 9–10/group). [3H]Spiperone binding in the frontal cortex was not consistently detected above background. One outlier was removed from the P35 group for nucleus accumbens. No significant effects of age were found by ANOVA.
| Age (Postnatal Day) | [3H]Spiperone Binding | |
|---|---|---|
| Bmax | KD | |
| fmol/mg protein | nM | |
| Caudate-putamen | ||
| 35 | 341 ± 20 | 0.12 ± 0.009 |
| 42 | 343 ± 17 | 0.13 ± 0.016 |
| 70 | 323 ± 19 | 0.13 ± 0.015 |
| Nucleus accumbens | ||
| 35 | 293 ± 23 | 0.76 ± 0.13 |
| 42 | 260 ± 15 | 0.52 ± 0.069 |
| 70 | 282 ± 23 | 0.60 ± 0.092 |