Noncompartmental analysis of rifampicin concentration versus time profiles in mice
Data are expressed as mean values from three mice per time point per day.
| Day | Matrix | Tmax | Cmax | AUC0–24 h |
|---|---|---|---|---|
| h | μM | μM · h | ||
| 1 | Serum | 4 | 10.2 | 120 |
| Liver | 4 | 38.7 | 571 | |
| 2 | Serum | 4 | 16.7 | 254 |
| Liver | 1 | 44.1 | 1036 | |
| 3 | Serum | 4 | 10.0 | 206 |
| Liver | 4 | 26.0 | 866 | |
| 4 | Serum | 8 | 2.07 | 34.3 |
| Liver | 8 | 11.7 | 235 |