VX challenge of wild-type mice
On day 4 postvirus injection mice were challenged subcutaneously with 2.5× LD50 of VX (28 μg/kg). The BChE activities shown are before challenge with VX.
| Mouse # | Virus | BChE | VX Exposure and Signs of Toxicity | |
|---|---|---|---|---|
| 1st 2.5× | 2nd 2.5× | |||
| U/ml | ||||
| 1 | Ad-control | 1.5 | Died in 3 min | |
| 2 | Ad-control | 1.8 | Died in 3 min | |
| 3 | Ad-control | 2.2 | Died in 3 min | |
| 4 | Ad-control | 1.2 | Died in 3 min | |
| 5 | Ad-control | 1.6 | Died in 3 min | |
| 6 | Ad-control | 2.7 | Died in 3 min | |
| 7 | Ad-control | 3.3 | Died in 3 min | |
| 8 | Ad-control | 3.4 | Died in 3 min | |
| 9 | Ad-control | 3.3 | Died in 3 min | |
| 10 | Ad-control | 2.9 | Died in 3 min | |
| 1 | Ad-MoBChE | 4150 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 2 | Ad-MoBChE | 2560 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 3 | Ad-MoBChE | 4050 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 4 | Ad-MoBChE | 2280 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 5 | Ad-MoBChE | 2290 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 6 | Ad-MoBChE | 2956 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 7 | Ad-MoBChE | 2190 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 8 | Ad-MoBChE | 3870 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 9 | Ad-MoBChE | 4290 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 10 | Ad-MoBChE | 2980 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 11 | Ad-MoBChE | 5760 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 12 | Ad-MoBChE | 4480 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 13 | Ad-MoBChE | 5419 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 14 | Ad-MoBChE | 2397 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |
| 15 | Ad-MoBChE | 3160 | No deaths or VX toxicity signs | No deaths or VX toxicity signs |