TABLE 2

Enhancement in rat brain levels of compound A by the P-gp inhibitor Elacridar

Compound A (3 mg/kg) was dosed intravenously in two rats. The P-gp inhibitor Elacridar (5 mg/kg) and compound A (3 mg/kg) were coadministered intravenously in two rats. Two hours after the intravenous administration, brain and plasma samples were obtained and analyzed for compound A by LC-MS/MS. The limits of quantitation were 20 ng/g for brain samples and 5 ng/ml for plasma samples.