TABLE 4 Effect of 2MEO on inflammatory mediator production by LPS/IFNγ-stimulated J774 macrophages in the presence and absence of ICI 182,780
Cells were pretreated with ICI 182,780 (1 h) and/or 2MEO (30 min). Cell supernatants were collected 24 h after stimulation for measurement of mediator concentrations. Data are expressed as mean ± S.E.M. (n = 4–5). The concentrations of IL-6, TNF-α, PGE2, and nitrite for the LPS + IFNγ response were 43 ± 7 ng · ml−1, 103 ± 11 ng · ml−1, 14 ± 1 ng · ml−1, and 57 ± 2 μM, respectively.