TABLE 1

Binding affinities Ki (nM) of BU08028, compared with buprenorphine, morphine, and other prototypical agonists at NOP and opioid receptors

Data show mean ± S.D. for at least two experiments conducted in triplicate. SR16435 data are from Khroyan et al., 2007.

Receptor Binding Ki ± S.D.
NOPμδκ
nM
Buprenorphine77.4 ± 16.11.52 ± 0.86.13 ± 0.42.50 ± 1.2
N/OFQ0.08 ± 0.03133 ± 30>10,000247 ± 3.4
DAMGO>10,0001.59 ± 0.17300 ± 58.6305 ± 46
DPDPE>10,000503 ± 10.01.24 ± 0.09>10,000
U69593>10,000>10,000>10,0001.62 ± 0.26
Etorphine56.9 ± 2.610.33 ± 0.051.54 ± 0.60.22 ± 0.05
SR164357.49 ± 1.312.70 ± 0.1>1,00031.7 ± 4.8
BU080288.46 ± 1.312.14 ± 0.791.59 ± 0.285.63 ± 1.30